Analyse - Methylation Survival Result | CGGA - Chinese Glioma Genome Altas

Analyse result - methylation data (survival)

Dataset:

mRNAseq_325

Gene:

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Data
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CGGA.ID	PRS.type	Histology	Grade	Gender	OS	Censor	Age	IDH.mutation.status	1p19q.codel.status	Gene.A.Expression	Gene.B.Expression
CGGA_1001	Primary	GBM	WHO IV	Male	3817	0	11		Wildtype	Non-codel	6.78	3.68
CGGA_1006	Primary	AA	WHO III	Male	254	1	42		Wildtype	Non-codel	2.06	3.39
CGGA_1007	Primary	GBM	WHO IV	Female	345	1	57		Wildtype	Non-codel	3.94	0.85
CGGA_1011	Primary	GBM	WHO IV	Female	109	1	46		Wildtype	Non-codel	3.16	4.12
CGGA_1015	Primary	GBM	WHO IV	Male	164	1	62		Wildtype	Non-codel	3.53	4.46
CGGA_1019	Recurrent	rGBM	WHO IV	Male	212	1	60		Wildtype	Non-codel	5	2.18
CGGA_1022	Recurrent	rA	WHO II	Female	518	0	62		Wildtype	Non-codel	5.81	7.11
CGGA_1023	Primary	GBM	WHO IV	Female	681	1	56		Wildtype	Non-codel	5.9	0.94
CGGA_1024	Primary	GBM	WHO IV	Male	3074	1	64		Wildtype	Non-codel	2.8	1.39
CGGA_1026	Primary	GBM	WHO IV	Male	1570	1	57		Wildtype	Non-codel	0.91	1.5
CGGA_1034	Primary	AA	WHO III	Male	753	1	23		Wildtype	Non-codel	3.96	3.04
CGGA_1035	Primary	GBM	WHO IV	Female	567	1	60		Wildtype	Non-codel	17.63	8.03
CGGA_1039	Primary	GBM	WHO IV	Male	727	1	40		Wildtype	Non-codel	1.1	0.55
CGGA_1045	Primary	GBM	WHO IV	Male	348	1	79		Wildtype	Non-codel	6.27	12.2
CGGA_1049	Primary	GBM	WHO IV	Male	809	1	58		Wildtype	Non-codel	15.79	2.46
CGGA_1052	Primary	O	WHO II	Male	NA	NA	41		Mutant	Codel	0.56	0.58
CGGA_1072	Primary	GBM	WHO IV	Male	1090	1	26		Wildtype	Non-codel	2.4	1.8
CGGA_1077	Primary	GBM	WHO IV	Male	591	1	47		Wildtype	Non-codel	4.26	2.05
CGGA_1078	Recurrent	rGBM	WHO IV	Female	315	1	61		Wildtype	Non-codel	1.97	3.85
CGGA_1079	Primary	AA	WHO III	Male	471	1	38		Wildtype	Non-codel	3.87	2.42
CGGA_1081	Recurrent	rAA	WHO III	Female	216	1	30		Wildtype	Non-codel	1.69	0.57
CGGA_1083	Primary	GBM	WHO IV	Male	450	1	59		Wildtype	Non-codel	4.48	2.43
CGGA_1091	Primary	GBM	WHO IV	Female	1116	1	51		Wildtype	Non-codel	2.73	0.86
CGGA_1109	Primary	GBM	WHO IV	Male	1348	1	42		Wildtype	Non-codel	1.87	2.97
CGGA_1124	Primary	GBM	WHO IV	Male	484	1	47		Wildtype	Non-codel	5.77	10.63
CGGA_1139	Primary	GBM	WHO IV	Female	1196	1	53		Wildtype	Non-codel	2.51	0.23
CGGA_1140	Recurrent	rAA	WHO III	Female	921	1	49		Wildtype	Non-codel	0.13	0.98
CGGA_1145	Recurrent	rAA	WHO III	Male	239	1	41		Wildtype	Non-codel	2.92	18.06
CGGA_1171	Primary	GBM	WHO IV	Male	412	1	40		Wildtype	Non-codel	9.37	2.5
CGGA_1177	Recurrent	rGBM	WHO IV	Male	449	1	40		Wildtype	Non-codel	6.75	3.69
CGGA_1180	Primary	GBM	WHO IV	Female	1226	0	48		Wildtype	Non-codel	3.39	2.32
CGGA_1188	Secondary	sGBM	WHO IV	Female	256	1	30		Mutant	Non-codel	3.37	1.19
CGGA_1214	Primary	GBM	WHO IV	Female	604	1	49		Wildtype	Non-codel	4.06	0.63
CGGA_1216	Primary	GBM	WHO IV	Male	312	1	44		Wildtype	Non-codel	8.44	1.06
CGGA_1218	Secondary	sGBM	WHO IV	Male	286	1	53		Wildtype	Non-codel	4.29	3.93
CGGA_1224	Primary	GBM	WHO IV	Male	271	1	57		Wildtype	Non-codel	9.17	2.56
CGGA_1234	Primary	GBM	WHO IV	Male	705	1	32		Wildtype	Non-codel	2.72	3.94
CGGA_1237	Primary	GBM	WHO IV	Male	296	1	62		Wildtype	Non-codel	1.55	2.75
CGGA_1240	Primary	GBM	WHO IV	Male	19	1	33		Wildtype	Non-codel	4.13	9.12
CGGA_1251	Primary	GBM	WHO IV	Female	272	1	42		Wildtype	Non-codel	2.08	1.06
CGGA_1258	Primary	GBM	WHO IV	Male	114	1	42		Wildtype	Non-codel	6.24	0.98
CGGA_1263	Primary	AA	WHO III	Male	772	1	50		Wildtype	Non-codel	3.3	1.17
CGGA_1270	Primary	GBM	WHO IV	Female	188	1	60		Wildtype	Non-codel	5.96	1.94
CGGA_1271	Recurrent	rGBM	WHO IV	Male	523	1	17		Wildtype	Non-codel	6.3	1.38
CGGA_1272	Secondary	sGBM	WHO IV	Male	124	1	32		Mutant	Non-codel	1.45	1.02
CGGA_1280	Primary	AA	WHO III	Male	447	1	74		Wildtype	Non-codel	7.55	0.9
CGGA_1281	Primary	AA	WHO III	Male	2909	0	45		Wildtype	Codel	0.43	0.86
CGGA_1283	Secondary	sGBM	WHO IV	Male	20	1	17		Wildtype	Non-codel	0.72	0.22
CGGA_1284	Primary	AA	WHO III	Male	97	1	73		Wildtype	Non-codel	6.52	7.23
CGGA_1285	Recurrent	rGBM	WHO IV	Female	79	1	58		Wildtype	Non-codel	17.61	0.31
CGGA_1292	Primary	AA	WHO III	Male	2901	0	17		Wildtype	Non-codel	0.55	0.67
CGGA_1299	Primary	GBM	WHO IV	Male	550	1	54		Wildtype	Non-codel	2.29	0.58
CGGA_1301	Secondary	sGBM	WHO IV	Male	239	1	48		Wildtype	Non-codel	1.39	2.56
CGGA_1313	Primary	GBM	WHO IV	Male	379	1	42		Wildtype	Non-codel	4.25	11.51
CGGA_1320	Primary	GBM	WHO IV	Male	59	1	19		Wildtype	Non-codel	30.45	0.44
CGGA_1332	Primary	GBM	WHO IV	Female	510	0	55		Wildtype	Non-codel	3.04	0.22
CGGA_1338	Primary	GBM	WHO IV	Female	1122	1	61		Wildtype	Non-codel	7.21	5.06
CGGA_1340	Primary	AA	WHO III	Male	1109	1	35		Wildtype	Non-codel	2.01	0.86
CGGA_1342	Primary	GBM	WHO IV	Male	186	1	47		Wildtype	Non-codel	6.13	4.64
CGGA_1343	Recurrent	rGBM	WHO IV	Male	94	1	34		Wildtype	Non-codel	1.36	2
CGGA_1346	Secondary	sGBM	WHO IV	Female	284	1	57		Wildtype	Non-codel	3.91	3.21
CGGA_1370	Recurrent	rGBM	WHO IV	Male	325	0	43		Wildtype	Non-codel	3.81	0.21
CGGA_1393	Secondary	sGBM	WHO IV	Male	275	1	41		Wildtype	Non-codel	3.84	3.75
CGGA_1408	Primary	AA	WHO III	Female	1362	1	64		Wildtype	Non-codel	2.57	1.41
CGGA_1411	Recurrent	rAA	WHO III	Female	329	1	40		Wildtype	Non-codel	3.99	2.05
CGGA_235	Primary	O	WHO II	Male	2340	1	24		Mutant	Codel	0.59	0.36
CGGA_269	Primary	A	WHO II	Female	2932	0	45		Wildtype	Non-codel	2.44	2.21
CGGA_272	Secondary	sGBM	WHO IV	Male	217	1	51		Wildtype	Non-codel	0.96	7.77
CGGA_274	Primary	GBM	WHO IV	Female	610	0	55		Wildtype	Non-codel	3.85	0.66
CGGA_276	Primary	O	WHO II	Male	529	0	44		Mutant	Non-codel	1.02	1.23
CGGA_309	NA	NA	NA	Male	139	1	44		Wildtype	NA	0.95	2.82
CGGA_318	Secondary	sGBM	WHO IV	Female	222	1	40		Wildtype	Non-codel	9.3	15.89
CGGA_323	Primary	O	WHO II	Female	4338	0	48		Wildtype	Non-codel	1.43	1.8
CGGA_330	Primary	AA	WHO III	Male	1121	1	45		Wildtype	Non-codel	3.04	2.87
CGGA_413	Primary	GBM	WHO IV	Male	183	0	54		Wildtype	Non-codel	2.11	1.83
CGGA_426	Primary	AA	WHO III	Male	1560	1	50		Wildtype	Non-codel	5.08	4.33
CGGA_448	Primary	AA	WHO III	Male	354	1	64		Wildtype	Non-codel	2.11	10.12
CGGA_483	Primary	GBM	WHO IV	Female	277	1	59		Wildtype	Non-codel	2.55	5.64
CGGA_488	Primary	AA	WHO III	Male	435	1	23		Wildtype	Non-codel	0.37	0.38
CGGA_493	Primary	A	WHO II	Female	2382	1	32		Mutant	Non-codel	0.47	0.82
CGGA_494	Primary	GBM	WHO IV	Female	4435	0	58		Wildtype	Non-codel	0.47	1.28
CGGA_495	NA	NA	NA	Male	295	1	53		Wildtype	NA	6.18	0.27
CGGA_499	Primary	GBM	WHO IV	Male	122	1	51		Wildtype	Non-codel	2.31	1.09
CGGA_525	Primary	GBM	WHO IV	Male	138	1	61		Wildtype	Non-codel	7.62	0.95
CGGA_541	Primary	A	WHO II	Female	4376	0	36		Wildtype	Non-codel	1.47	2.6
CGGA_564	Primary	AA	WHO III	Male	679	1	47		Wildtype	Non-codel	3.26	1.9
CGGA_565	Primary	AA	WHO III	Male	3605	0	51		Wildtype	Non-codel	0.52	0.74
CGGA_578	Primary	AA	WHO III	Female	362	1	61		Wildtype	Non-codel	7.43	0.82
CGGA_599	Primary	AO	WHO III	Female	418	1	66		Wildtype	Non-codel	1.84	0.58
CGGA_604	Primary	GBM	WHO IV	Male	381	1	46		Wildtype	Non-codel	9.28	12.85
CGGA_616	Primary	AA	WHO III	Male	952	1	43		Wildtype	Non-codel	5.14	1.8
CGGA_624	Recurrent	rGBM	WHO IV	Female	122	1	50		Wildtype	Non-codel	8.98	3.74
CGGA_630	Recurrent	rO	WHO III	Male	4300	0	43		Mutant	Codel	0.51	0.75
CGGA_633	Primary	O	WHO II	Female	1812	1	56		Wildtype	Non-codel	3.09	1.36
CGGA_638	Primary	O	WHO II	Male	2386	0	42		Mutant	Codel	1.4	0.89
CGGA_643	Primary	AA	WHO III	Male	331	1	56		Wildtype	Non-codel	1.42	1.65
CGGA_658	Primary	GBM	WHO IV	Male	372	1	55		Wildtype	Non-codel	2.76	0.94
CGGA_659	Primary	O	WHO II	Female	730	0	50		Wildtype	Non-codel	1.24	1.01
CGGA_661	Primary	AA	WHO III	Male	NA	1	42		Wildtype	Non-codel	5.78	6.51
CGGA_669	Recurrent	rGBM	WHO IV	Female	607	1	56		Wildtype	Codel	0.37	0.76
CGGA_676	Primary	GBM	WHO IV	Male	376	1	60		Wildtype	Non-codel	3.08	6.01
CGGA_678	Recurrent	rAA	WHO III	Male	386	1	56		Wildtype	Non-codel	5.14	7.18
CGGA_679	Primary	GBM	WHO IV	Female	263	1	63		Wildtype	Non-codel	2.3	2.76
CGGA_680	Primary	GBM	WHO IV	Male	2373	1	44		Wildtype	Non-codel	0.54	0.91
CGGA_681	NA	NA	NA	Male	110	1	42		Wildtype	NA	1.28	3.02
CGGA_700	Primary	GBM	WHO IV	Female	170	0	24		Mutant	Non-codel	0.8	1.68
CGGA_727	Primary	AA	WHO III	Male	1023	1	45		Wildtype	Non-codel	1.22	2.02
CGGA_731	Primary	GBM	WHO IV	Male	503	1	50		Wildtype	Non-codel	5.25	3.38
CGGA_732	Primary	AA	WHO III	Female	NA	NA	35		Wildtype	Non-codel	0.53	0.59
CGGA_766	Primary	O	WHO II	Male	4103	0	32		Mutant	Codel	0.48	0.47
CGGA_773	Secondary	sGBM	WHO IV	Female	443	1	51		Mutant	Non-codel	0.72	1.11
CGGA_782	Primary	GBM	WHO IV	Male	289	1	60		Wildtype	Non-codel	6.78	1.62
CGGA_789	Primary	GBM	WHO IV	Male	345	1	50		Wildtype	Non-codel	9.14	2.13
CGGA_791	Primary	AA	WHO III	Male	252	1	55		Wildtype	Non-codel	1.05	1.05
CGGA_796	Primary	A	WHO II	Male	559	0	60		Wildtype	Non-codel	3.86	1.17
CGGA_802	Primary	GBM	WHO IV	Male	681	1	42		Wildtype	Non-codel	7.75	7.25
CGGA_804	Primary	GBM	WHO IV	Female	614	0	53		Wildtype	Non-codel	1.55	0.56
CGGA_807	Primary	A	WHO II	Male	4040	0	42		Wildtype	Non-codel	0.35	0.32
CGGA_808	Primary	GBM	WHO IV	Male	1167	0	38		Wildtype	Non-codel	1.5	2.05
CGGA_837	Primary	GBM	WHO IV	Male	432	1	57		Wildtype	Non-codel	3.39	3.78
CGGA_842	Primary	GBM	WHO IV	Female	204	1	63		Wildtype	Non-codel	7.43	3.2
CGGA_848	Primary	GBM	WHO IV	Female	239	0	54		Wildtype	Non-codel	3.25	0.84
CGGA_850	Primary	GBM	WHO IV	Female	564	0	52		Wildtype	Non-codel	2.06	1.79
CGGA_859	Primary	GBM	WHO IV	Male	387	1	56		Wildtype	Non-codel	8.78	7.04
CGGA_871	Primary	O	WHO II	Male	3964	0	37		Mutant	Codel	1.39	1.45
CGGA_876	Primary	GBM	WHO IV	Female	159	1	60		Wildtype	Non-codel	7.15	4.41
CGGA_878	Primary	GBM	WHO IV	Male	863	1	42		Wildtype	Non-codel	3.14	8.18
CGGA_902	Primary	GBM	WHO IV	Male	193	1	54		Wildtype	Non-codel	2.06	1.27
CGGA_D02	Recurrent	rGBM	WHO IV	Male	484	1	44		Wildtype	Non-codel	8.8	0.65
CGGA_D03	Primary	GBM	WHO IV	Male	423	1	44		Wildtype	Non-codel	2.35	9.02
CGGA_D06	Recurrent	rAA	WHO III	Female	NA	1	49		Wildtype	Codel	1.6	0.77
CGGA_D09	Primary	GBM	WHO IV	Male	233	1	57		Wildtype	Non-codel	8.12	1.77
CGGA_D11	Primary	AA	WHO III	Female	827	1	53		Wildtype	Non-codel	2.53	2.5
CGGA_D16	Primary	AA	WHO III	Female	261	1	59		Wildtype	Non-codel	3.62	1.32
CGGA_D18	Primary	AA	WHO III	Male	NA	NA	20		Wildtype	Non-codel	0.64	2.08
CGGA_D26	Recurrent	rGBM	WHO IV	Male	263	1	55		Wildtype	Non-codel	7.3	6.47
CGGA_D32	Recurrent	rGBM	WHO IV	Male	358	1	61		Wildtype	Non-codel	2.64	2.01
CGGA_D35	Primary	GBM	WHO IV	Female	661	1	68		Wildtype	Non-codel	7.44	3.47
CGGA_D36	Recurrent	rGBM	WHO IV	Male	34	1	58		Wildtype	Non-codel	5.36	1.33
CGGA_D37	Primary	GBM	WHO IV	Male	965	1	55		Wildtype	Non-codel	13.48	2.4
CGGA_D44	Primary	AA	WHO III	Female	313	1	18		Wildtype	Non-codel	9.07	1.66
CGGA_D51	Recurrent	rGBM	WHO IV	Female	135	1	60		Wildtype	Non-codel	7.08	5.97
CGGA_D57	Primary	GBM	WHO IV	Male	766	1	40		Wildtype	Non-codel	5.15	1.36
CGGA_D58	Recurrent	rAA	WHO III	Male	181	1	24		Wildtype	Codel	0.54	0.63
CGGA_342	Primary	GBM	WHO IV	Female	500	1	49		Wildtype	NA	1.91	3.02
CGGA_719	Secondary	sGBM	WHO IV	Male	101	1	51		Mutant	NA	0.3	0.7
CGGA_J030	Primary	O	WHO II	Male	3389	0	38		Mutant	Codel	0.25	0.8
CGGA_J130	Recurrent	rA	WHO II	Male	3116	0	40		Wildtype	Non-codel	1.09	1.44
CGGA_1005	Primary	A	WHO II	Female	3815	0	41		Mutant	Non-codel	0.4	0.67
CGGA_1013	Primary	A	WHO II	Female	1725	1	38		Mutant	Non-codel	0.94	0.71
CGGA_1020	Primary	A	WHO II	Female	1120	1	38		Mutant	Non-codel	1.12	0.94
CGGA_1027	Primary	AO	WHO III	Male	2688	0	37		Mutant	Codel	2.18	2.37
CGGA_1031	Primary	A	WHO II	Female	2457	1	31		Mutant	Non-codel	0.6	0.64
CGGA_1046	Primary	A	WHO II	Male	3559	0	21		NA	NA	0.43	0.36
CGGA_1050	Primary	O	WHO II	Male	NA	0	39		Mutant	Codel	0.38	0.54
CGGA_1060	Recurrent	rGBM	WHO IV	Male	227	1	42		Mutant	Non-codel	0.99	0.58
CGGA_1061	Recurrent	rAA	WHO III	Female	532	1	43		Mutant	Non-codel	1.16	0.25
CGGA_1068	Secondary	sGBM	WHO IV	Male	68	1	29		Mutant	Non-codel	2.12	1.01
CGGA_1094	Recurrent	rAA	WHO III	Female	252	1	40		Mutant	Non-codel	1.06	1.74
CGGA_1105	Secondary	sGBM	WHO IV	Male	609	1	29		Mutant	Non-codel	2.88	6.42
CGGA_1113	Primary	AO	WHO III	Male	1265	1	34		Mutant	Codel	0.52	0.45
CGGA_1129	Secondary	sGBM	WHO IV	Male	168	1	34		Mutant	Non-codel	3.12	0.4
CGGA_1136	Secondary	sGBM	WHO IV	Female	236	1	38		Mutant	Non-codel	1.44	1.12
CGGA_1146	Primary	AA	WHO III	Male	2498	0	35		Mutant	Non-codel	1.48	1.46
CGGA_1160	Primary	AA	WHO III	Female	426	1	43		Mutant	Non-codel	1.4	1.49
CGGA_1170	Secondary	sGBM	WHO IV	Male	346	1	25		Mutant	Non-codel	0.33	0.75
CGGA_1175	Secondary	sGBM	WHO IV	Female	441	1	36		Mutant	Non-codel	0.8	0.56
CGGA_1189	Primary	AO	WHO III	Female	3082	0	34		Mutant	Codel	0.9	0.59
CGGA_1190	Primary	AA	WHO III	Female	3082	0	45		Mutant	Non-codel	0.95	1.85
CGGA_1215	Recurrent	rAA	WHO III	Male	29	1	37		Mutant	Non-codel	2.24	0.73
CGGA_1219	Primary	GBM	WHO IV	Female	2120	1	57		Mutant	Non-codel	0.92	0.29
CGGA_1227	Recurrent	rGBM	WHO IV	Female	1197	1	46		Wildtype	Non-codel	5.98	2.36
CGGA_1231	Recurrent	rAA	WHO III	Female	2279	1	31		Wildtype	Non-codel	10.6	4.5
CGGA_1287	Primary	GBM	WHO IV	Male	533	1	29		Mutant	Non-codel	0.7	0.88
CGGA_1307	Primary	AA	WHO III	Female	965	0	25		Mutant	Non-codel	3.71	1.95
CGGA_1314	Primary	GBM	WHO IV	Female	172	1	27		Mutant	Non-codel	1.9	0.79
CGGA_1322	Primary	AA	WHO III	Male	253	1	10		Mutant	Non-codel	1.04	0.34
CGGA_1324	Secondary	sGBM	WHO IV	Male	848	1	42		Mutant	Codel	0.65	0.88
CGGA_1329	Recurrent	rAA	WHO III	Female	326	1	43		Mutant	Non-codel	0.2	2.3
CGGA_1330	Primary	A	WHO II	Male	2846	0	47		Mutant	Non-codel	1.35	0.81
CGGA_1374	Recurrent	rAA	WHO III	Male	141	1	22		Mutant	Non-codel	0.56	4.17
CGGA_1375	Secondary	sGBM	WHO IV	Female	92	1	50		Mutant	Non-codel	0.35	0.18
CGGA_1381	Recurrent	rGBM	WHO IV	Female	46	1	36		Mutant	Non-codel	1.2	0.36
CGGA_1384	Primary	GBM	WHO IV	Female	191	1	39		Mutant	Non-codel	0.28	1.41
CGGA_1388	Recurrent	rAA	WHO III	Male	485	1	37		Mutant	Non-codel	0.94	4.82
CGGA_1394	Recurrent	rGBM	WHO IV	Male	139	1	37		Mutant	Non-codel	0.33	0.43
CGGA_1406	Primary	A	WHO II	Male	2154	1	34		Mutant	Non-codel	3.21	0.77
CGGA_1409	Primary	GBM	WHO IV	Female	2727	0	24		Mutant	Non-codel	0.67	0.98
CGGA_1412	Secondary	sGBM	WHO IV	Female	296	1	48		Mutant	Codel	0.78	2.39
CGGA_171	Primary	O	WHO II	Female	NA	NA	37		Mutant	Codel	1.36	0.62
CGGA_236	Primary	O	WHO II	Male	706	0	47		Mutant	Codel	0.36	0.16
CGGA_241	Primary	A	WHO II	Male	4809	0	34		Mutant	Non-codel	1.84	1.29
CGGA_245	Recurrent	rAA	WHO III	Female	318	1	39		Mutant	Non-codel	1.55	1.91
CGGA_251	Primary	A	WHO II	Male	1299	0	45		Mutant	Non-codel	1.67	1.44
CGGA_252	Primary	A	WHO II	Female	165	0	24		Mutant	Non-codel	0.48	1.13
CGGA_254	Primary	O	WHO II	Male	4793	0	38		Mutant	Codel	1.15	0.5
CGGA_256	Primary	A	WHO II	Male	158	0	39		Mutant	Non-codel	0.91	1.3
CGGA_261	Primary	A	WHO II	Male	4130	0	27		Mutant	Non-codel	0.39	0.36
CGGA_267	Primary	A	WHO II	Male	1374	1	36		Mutant	Non-codel	0.68	0.38
CGGA_273	Primary	A	WHO II	Female	2635	1	35		Mutant	Non-codel	1.67	2.79
CGGA_283	Primary	O	WHO II	Female	3470	1	47		Mutant	Codel	1.07	1.08
CGGA_300	Primary	A	WHO II	Female	2199	1	35		Mutant	Non-codel	0.73	0.79
CGGA_314	Recurrent	rO	WHO III	Male	2568	1	39		Mutant	Codel	0.6	1.42
CGGA_333	Primary	A	WHO II	Male	1783	0	40		Mutant	Non-codel	1.76	1.56
CGGA_337	Primary	AA	WHO III	Female	1008	1	50		Mutant	Non-codel	2.07	2.53
CGGA_374	Secondary	sGBM	WHO IV	Male	493	1	37		Mutant	Non-codel	0.34	0.53
CGGA_400	Recurrent	rAA	WHO III	Female	1321	1	38		Mutant	Non-codel	1.4	0.96
CGGA_431	Recurrent	rO	WHO III	Male	4515	0	41		Mutant	Codel	0.77	0.57
CGGA_446	Primary	O	WHO II	Female	4508	0	35		Mutant	Codel	0.67	0.25
CGGA_458	Recurrent	rA	WHO II	Male	419	1	51		Mutant	Non-codel	0.43	1
CGGA_479	Primary	O	WHO II	Female	4445	0	36		Mutant	Codel	0.77	0.64
CGGA_485	Primary	O	WHO II	Male	2437	0	31		Mutant	Codel	0.59	0.77
CGGA_490	Primary	AO	WHO III	Female	3804	0	37		Mutant	Codel	0.72	0.74
CGGA_491	Primary	GBM	WHO IV	Female	1074	1	36		Mutant	Non-codel	1.31	0.84
CGGA_501	Primary	O	WHO II	Male	4427	0	40		Mutant	Codel	0.61	1.82
CGGA_502	Primary	A	WHO II	Male	4414	0	39		Mutant	Non-codel	0.46	0.92
CGGA_510	Primary	AO	WHO III	Male	4403	0	42		Mutant	Codel	0.4	0.91
CGGA_538	Primary	O	WHO II	Female	NA	NA	43		Mutant	Codel	1.22	0.74
CGGA_543	Primary	O	WHO II	Male	4371	0	43		Mutant	Codel	0.58	0.66
CGGA_545	Recurrent	rGBM	WHO IV	Female	555	1	38		Mutant	Non-codel	1.92	4.63
CGGA_551	Primary	O	WHO II	Male	4363	0	44		Mutant	Codel	0.36	0.39
CGGA_560	Primary	AA	WHO III	Male	4354	0	43		Mutant	Non-codel	1.39	1.38
CGGA_580	Primary	A	WHO II	Male	1394	1	43		Mutant	Non-codel	0.26	1.49
CGGA_591	Primary	AA	WHO III	Female	1654	1	50		Mutant	Non-codel	1.21	2.07
CGGA_598	Primary	AO	WHO III	Female	3677	1	61		Mutant	Codel	0.23	0.59
CGGA_601	Primary	A	WHO II	Male	1133	1	36		Mutant	Non-codel	1.78	0.91
CGGA_603	Recurrent	rAA	WHO III	Male	168	0	32		Mutant	Non-codel	1.63	1.48
CGGA_605	Recurrent	rA	WHO III	Male	4300	0	43		Mutant	Non-codel	2.9	3.16
CGGA_607	Primary	A	WHO II	Male	1389	0	25		Mutant	Non-codel	0.5	1.01
CGGA_632	Primary	A	WHO II	Female	576	1	29		Mutant	Non-codel	0.86	0.45
CGGA_635	Primary	O	WHO II	Male	4263	0	45		Mutant	Codel	0.49	0.9
CGGA_641	Primary	AO	WHO III	Female	3411	1	51		Mutant	Codel	0.57	0.35
CGGA_642	Primary	A	WHO II	Male	4249	0	29		Mutant	Non-codel	0.43	0.96
CGGA_655	Primary	O	WHO II	Male	4231	0	35		Mutant	Codel	1.07	0.7
CGGA_662	Primary	O	WHO II	Female	284	1	59		Mutant	Codel	0.41	0.82
CGGA_666	Primary	O	WHO II	Female	2499	1	45		Mutant	Codel	0.58	1.2
CGGA_671	Primary	O	WHO II	Female	4215	0	36		Mutant	Codel	0.79	0.64
CGGA_675	Primary	O	WHO II	Female	4210	0	23		Mutant	Codel	0.61	0.42
CGGA_685	Primary	A	WHO II	Female	3239	1	20		Mutant	Non-codel	0.91	0.65
CGGA_689	Primary	O	WHO II	Female	4194	0	36		Mutant	Codel	1.08	0.7
CGGA_694	Recurrent	rA	WHO II	Male	1194	1	34		Mutant	Non-codel	1.78	1.05
CGGA_698	Primary	A	WHO II	Female	1851	1	61		Mutant	Non-codel	0.89	1.02
CGGA_704	Primary	A	WHO II	Male	2572	1	36		Mutant	Non-codel	0.99	1.26
CGGA_710	Primary	GBM	WHO IV	Male	660	1	41		Mutant	Non-codel	1.42	1.57
CGGA_715	Primary	O	WHO II	Male	3429	0	43		Mutant	Codel	0.54	0.69
CGGA_725	Primary	O	WHO II	Male	4147	0	58		Mutant	Codel	0.94	0.93
CGGA_747	Primary	GBM	WHO IV	Male	970	1	29		Mutant	Non-codel	0.6	0.25
CGGA_752	Primary	O	WHO II	Male	3680	0	39		Mutant	Codel	0.54	1.69
CGGA_757	Primary	A	WHO II	Male	1047	1	45		Mutant	Non-codel	0.41	0.75
CGGA_760	Primary	O	WHO II	Female	4110	0	34		Mutant	Codel	0.4	0.66
CGGA_761	Primary	GBM	WHO IV	Male	1840	1	45		Mutant	Non-codel	1.06	0.8
CGGA_762	Primary	O	WHO II	Female	4105	0	40		Mutant	Codel	0.59	0.62
CGGA_785	Primary	O	WHO II	Male	3517	1	43		Mutant	Codel	0.28	0.76
CGGA_812	Primary	O	WHO II	Male	4035	0	27		Mutant	Codel	0.88	1.21
CGGA_815	Primary	A	WHO II	Female	2219	1	53		Mutant	Non-codel	1.67	2.23
CGGA_818	Primary	A	WHO II	Male	4027	0	46		Mutant	Non-codel	1.08	4.53
CGGA_822	Secondary	sGBM	WHO IV	Male	2237	1	46		Mutant	Non-codel	0.32	0.21
CGGA_834	Primary	A	WHO II	Male	4013	0	24		Wildtype	Non-codel	3.57	1.56
CGGA_835	Primary	O	WHO II	Male	517	0	31		Mutant	Codel	0.59	0.69
CGGA_838	Primary	O	WHO II	Female	4011	0	36		Mutant	Codel	0.34	0.42
CGGA_843	Primary	O	WHO II	Male	4005	0	29		Mutant	Codel	0.84	0.37
CGGA_856	Primary	O	WHO II	Male	1297	0	53		Mutant	Codel	0.24	0.22
CGGA_858	Primary	O	WHO II	Male	3984	0	42		Mutant	Codel	0.22	0.72
CGGA_864	Primary	O	WHO II	Male	3977	0	34		Mutant	Codel	0.45	0.69
CGGA_884	Primary	A	WHO II	Female	1131	1	48		Mutant	Non-codel	0.79	0.41
CGGA_892	Primary	O	WHO II	Male	448	0	34		Mutant	Codel	1.01	0.62
CGGA_893	Primary	A	WHO II	Female	3160	1	36		Mutant	Non-codel	0.63	0.49
CGGA_898	Primary	A	WHO II	Male	1663	1	38		Mutant	Non-codel	0.57	0.58
CGGA_899	Recurrent	rGBM	WHO IV	Male	231	1	48		Mutant	Non-codel	0.7	0.36
CGGA_904	Primary	A	WHO II	Male	774	1	33		Mutant	Non-codel	0.31	0.55
CGGA_905	Primary	A	WHO II	Male	3174	1	46		Mutant	Non-codel	0.74	1.05
CGGA_908	Primary	A	WHO II	Male	2436	1	35		Mutant	Non-codel	0.45	0.85
CGGA_909	Primary	A	WHO II	Female	3920	0	39		Mutant	Non-codel	2.43	1.95
CGGA_D04	Primary	A	WHO II	Male	3697	0	37		Mutant	Non-codel	0.18	0.36
CGGA_D07	Primary	O	WHO II	Male	3691	0	36		Mutant	Codel	1.35	0.95
CGGA_D14	Recurrent	rAA	WHO III	Male	NA	NA	27		Mutant	Non-codel	0.98	0.61
CGGA_D15	Primary	O	WHO II	Female	3669	0	38		Mutant	Codel	0.47	0.26
CGGA_D20	Primary	A	WHO II	Female	2367	1	40		Mutant	Non-codel	0.3	0.82
CGGA_D21	Primary	AA	WHO III	Female	1208	1	37		Mutant	Non-codel	1.1	1.68
CGGA_D24	Primary	AA	WHO III	Female	837	1	37		Mutant	Non-codel	1.13	1.08
CGGA_D27	Recurrent	rO	WHO III	Male	3650	0	33		Mutant	Codel	1.34	1.22
CGGA_D29	Primary	O	WHO II	Male	3643	0	36		Mutant	Codel	0.38	0.26
CGGA_D33	Recurrent	rAA	WHO III	Male	116	1	38		Mutant	Non-codel	1.36	1.11
CGGA_D34	Secondary	sGBM	WHO IV	Male	147	1	45		Mutant	Non-codel	0.82	1.06
CGGA_D38	Recurrent	rGBM	WHO IV	Female	689	1	41		Mutant	Codel	0.43	0.81
CGGA_D39	Recurrent	rA	WHO II	Female	NA	NA	27		Mutant	Non-codel	0.99	1.93
CGGA_D40	Recurrent	rA	WHO II	Male	3557	0	44		Mutant	Non-codel	1.7	0.73
CGGA_D45	Recurrent	rAA	WHO III	Male	856	0	32		Mutant	Non-codel	1.43	3.06
CGGA_D46	Recurrent	rAA	WHO III	Female	300	1	36		Mutant	Non-codel	1.15	2.37
CGGA_D47	Primary	O	WHO II	Male	1048	1	36		Mutant	Codel	2.06	1.34
CGGA_D48	Recurrent	rAA	WHO III	Female	221	1	23		Mutant	Non-codel	0.57	0.63
CGGA_D52	Primary	AO	WHO III	Male	3529	0	46		Mutant	Codel	0.34	0.7
CGGA_D56	Recurrent	rAA	WHO III	Male	64	1	45		Mutant	Non-codel	2.64	2.06
CGGA_D59	Secondary	sGBM	WHO IV	Female	NA	NA	30		Mutant	Non-codel	0.52	0.75
CGGA_277	Primary	AO	WHO III	Male	4739	0	40		Mutant	NA	1.06	0.8
CGGA_518	Secondary	sGBM	WHO IV	Male	212	1	27		Mutant	NA	0.53	0.17
CGGA_J023	Primary	AO	WHO III	Male	1028	1	36		Mutant	Non-codel	0.23	0.31
CGGA_J024	Recurrent	rA	WHO II	Female	3410	0	29		Mutant	Non-codel	0.62	2.13
CGGA_J042	Recurrent	rA	WHO II	Male	1409	1	38		Mutant	Non-codel	3.53	0.99
CGGA_J100	Recurrent	rGBM	WHO IV	Male	NA	NA	55		Mutant	Non-codel	1.43	0.82
CGGA_1004	Primary	A	WHO II	Female	899	1	63		Wildtype	Non-codel	17.04	1.96
CGGA_1008	Primary	GBM	WHO IV	Female	315	1	54		Wildtype	Non-codel	1.95	2.5
CGGA_1053	Primary	GBM	WHO IV	Female	370	1	63		Wildtype	Non-codel	2.81	2.38
CGGA_1059	Recurrent	rA	WHO II	Female	21	1	54		Mutant	Non-codel	0.86	0.69
CGGA_1070	Primary	GBM	WHO IV	Male	333	1	37		Wildtype	Non-codel	3.38	0.97
CGGA_1071	Primary	A	WHO II	Male	3252	1	42		Wildtype	Non-codel	4.32	2.25
CGGA_1073	Primary	GBM	WHO IV	Female	270	1	42		Wildtype	Non-codel	2.63	4.82
CGGA_1074	Primary	GBM	WHO IV	Male	86	1	50		Wildtype	Non-codel	8.23	2.38
CGGA_1095	NA	NA	NA	Male	2778	1	29		Mutant	Non-codel	0.42	0.71
CGGA_1099	Secondary	sGBM	WHO IV	Male	122	1	8		Wildtype	Non-codel	2.25	1.52
CGGA_1114	Primary	GBM	WHO IV	Male	460	1	53		Wildtype	Non-codel	7.19	2.58
CGGA_1116	Recurrent	rGBM	WHO IV	Female	248	1	43		Mutant	Non-codel	0.32	1.76
CGGA_1118	Recurrent	rAA	WHO III	Male	398	1	31		Mutant	Non-codel	0.79	0.46
CGGA_1119	Recurrent	rGBM	WHO IV	Male	422	1	52		Mutant	Codel	3.61	0.27
CGGA_1197	Secondary	sGBM	WHO IV	Male	942	1	43		Mutant	Codel	0.66	1.1
CGGA_1246	Primary	AO	WHO III	Male	2972	0	53		Mutant	Codel	0.49	0.87
CGGA_1275	Primary	GBM	WHO IV	Male	183	1	70		Wildtype	Non-codel	2.55	0.99
CGGA_1450	Secondary	sGBM	WHO IV	Male	957	1	37		Mutant	Codel	0.42	0.43
CGGA_1460	Secondary	sGBM	WHO IV	Male	209	1	51		Wildtype	Non-codel	1.58	0.82
CGGA_1475	Secondary	sGBM	WHO IV	Male	182	1	38		Mutant	Non-codel	1.38	1.34
CGGA_243	Primary	O	WHO II	Female	2977	0	30		Mutant	Codel	0.53	0.49
CGGA_247	Primary	AA	WHO III	Male	609	1	60		Mutant	Non-codel	1.28	0.48
CGGA_738	Primary	A	WHO II	Male	4132	0	43		Mutant	Non-codel	3.44	5.89
CGGA_759	Primary	GBM	WHO IV	Male	1263	1	30		Mutant	Non-codel	1.13	0.7
CGGA_D30	Primary	GBM	WHO IV	Male	215	1	70		Wildtype	Non-codel	3.28	0.82

data.file<-"data.txt"
gene<-"ADAMTSL4"

## load R package
library(survminer)
library(survival)
library(ggpubr)
library(gridExtra)

## import data
dat<-read.table(data.file, sep='\t', head=T)
rownames(dat)<-dat$CGGA.ID
#head(dat)
mat<-dat[!is.na(dat$PRS.type)&(dat$PRS.type=="Primary"|dat$PRS.type=="Recurrent")&
           !is.na(dat$Grade)&
           !is.na(dat$OS)&
           !is.na(dat$Censor),]

### all grade - Primary ###
matt<-mat[mat$PRS.type=='Primary',]
med.methyl<-median(matt$Methylation)
more.med.methyl.index<-which(matt$Methylation>=med.methyl)
less.med.methyl.index<-which(matt$Methylation< med.methyl)
matt$status<-NA
matt$status[more.med.methyl.index]<-paste0('High (',length(more.med.methyl.index),')')
matt$status[less.med.methyl.index]<-paste0('Low (',length(less.med.methyl.index),')')

s.fit<-survfit(Surv(OS, Censor) ~ status, data = matt)
s.diff<-survdiff(Surv(OS, Censor) ~ status, data = matt)

sdata.plot1<-ggsurvplot(s.fit,
                        data=matt,
                        pval = TRUE,
                        #conf.int = TRUE,
                        xlab = 'Time (day)',
                        ggtheme = theme_light(),
                        surv.median.line = 'hv',
                        title=paste0("All WHO grade survival (primary glioma)"))

### all grade - Recurrent ###
matt<-mat[mat$PRS.type=='Recurrent',]
med.methyl<-median(matt$Methylation)
more.med.methyl.index<-which(matt$Methylation>=med.methyl)
less.med.methyl.index<-which(matt$Methylation< med.methyl)
matt$status<-NA
matt$status[more.med.methyl.index]<-paste0('High (',length(more.med.methyl.index),')')
matt$status[less.med.methyl.index]<-paste0('Low (',length(less.med.methyl.index),')')

s.fit<-survfit(Surv(OS, Censor) ~ status, data = matt)
s.diff<-survdiff(Surv(OS, Censor) ~ status, data = matt)

sdata.plot2<-ggsurvplot(s.fit,
                        data=matt,
                        pval = TRUE,
                        #conf.int = TRUE,
                        xlab = 'Time (day)',
                        ggtheme = theme_light(),
                        surv.median.line = 'hv',
                        title=paste0("All WHO grade survival (recurrent glioma)"))

### WHO grade II - Primary ###
matt<-mat[mat$PRS.type=='Primary'&mat$Grade=="WHO II",]
med.methyl<-median(matt$Methylation)
more.med.methyl.index<-which(matt$Methylation>=med.methyl)
less.med.methyl.index<-which(matt$Methylation< med.methyl)
matt$status<-NA
matt$status[more.med.methyl.index]<-paste0('High (',length(more.med.methyl.index),')')
matt$status[less.med.methyl.index]<-paste0('Low (',length(less.med.methyl.index),')')

s.fit<-survfit(Surv(OS, Censor) ~ status, data = matt)
s.diff<-survdiff(Surv(OS, Censor) ~ status, data = matt)

sdata.plot3<-ggsurvplot(s.fit,
                        data=matt,
                        pval = TRUE,
                        #conf.int = TRUE,
                        xlab = 'Time (day)',
                        ggtheme = theme_light(),
                        surv.median.line = 'hv',
                        title=paste0("WHO grade II survival (primary glioma)"))

### WHO grade III - Primary ###
matt<-mat[mat$PRS.type=='Primary'&mat$Grade=="WHO III",]
med.methyl<-median(matt$Methylation)
more.med.methyl.index<-which(matt$Methylation>=med.methyl)
less.med.methyl.index<-which(matt$Methylation< med.methyl)
matt$status<-NA
matt$status[more.med.methyl.index]<-paste0('High (',length(more.med.methyl.index),')')
matt$status[less.med.methyl.index]<-paste0('Low (',length(less.med.methyl.index),')')

s.fit<-survfit(Surv(OS, Censor) ~ status, data = matt)
s.diff<-survdiff(Surv(OS, Censor) ~ status, data = matt)

sdata.plot4<-ggsurvplot(s.fit,
                        data=matt,
                        pval = TRUE,
                        #conf.int = TRUE,
                        xlab = 'Time (day)',
                        ggtheme = theme_light(),
                        surv.median.line = 'hv',
                        title=paste0("WHO grade III survival (primary glioma)"))

### WHO grade IV - Primary ###
matt<-mat[mat$PRS.type=='Primary'&mat$Grade=="WHO IV",]
med.methyl<-median(matt$Methylation)
more.med.methyl.index<-which(matt$Methylation>=med.methyl)
less.med.methyl.index<-which(matt$Methylation< med.methyl)
matt$status<-NA
matt$status[more.med.methyl.index]<-paste0('High (',length(more.med.methyl.index),')')
matt$status[less.med.methyl.index]<-paste0('Low (',length(less.med.methyl.index),')')

s.fit<-survfit(Surv(OS, Censor) ~ status, data = matt)
s.diff<-survdiff(Surv(OS, Censor) ~ status, data = matt)
sdata.plot5<-ggsurvplot(s.fit,
                        data=matt,
                        pval = TRUE,
                        #conf.int = TRUE,
                        xlab = 'Time (day)',
                        ggtheme = theme_light(),
                        surv.median.line = 'hv',
                        title=paste0("WHO grade IV survival (primary glioma)"))

## output pdf 
splots <- list()
splots[[1]]<-sdata.plot1
splots[[4]]<-sdata.plot2
splots[[2]]<-sdata.plot3
splots[[5]]<-sdata.plot4
splots[[3]]<-sdata.plot5
arrange_ggsurvplots(splots,nrow=3,ncol=2)

Analyse result - methylation data (survival)

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